DNA2.0, Inc. (http://www.DNA20.com), a leader in synthetic biology and the largest US provider
of synthetic genes has been awarded an SBIR/NSF grant to further expand their expertise in protein expression and to develop an automated multivariate machine learning algorithm for optimizing synthetic gene design.
Recombinant DNA technologies launched the biotechnology industry by allowing cost-effective production of valuable therapeutic proteins in easily cultured and manipulated organisms. Despite the early success of biotechnology, protein expression of recombinant genes remains a key
limiting step.
Efficient gene synthesis technology allows the complete redesign of any gene to meet new engineering requirement. DNA2.0 is using its expertise in machine learning algorithms to identify the critical variables and their impacts on protein expression. A multivariate array of genes will be
synthesized in DNA2.0’s state-of-the-art gene manufacturing facility, and then tested. The resulting multidimensional sequence-expression landscape will be modeled and resulting algorithm incorporated into Gene Designer(TM), a freely available software for the design of synthetic genes.
“We are designing and manufacturing a unique set of synthetic genes that will systematically identify and explore gene design parameters that affect protein expression,” said Mark Welch, PhD., project manager. “By applying experimental design methods that are widely used in other engineering disciplines, we intend to enable simple, automated gene designs that routinely optimize protein expression.”
“This project is a perfect fit for DNA2.0 and our goal to industrialize biotechnology,” said Jeremy Minshull, PhD., President of DNA2.0. “Systematic studies allow us to move from anecdotal evidence to science, and we know that robust and reliable protein expression is valuable to our customers.”
About DNA2.0, Inc.
DNA2.0 a leader in synthetic biology and is the developer of two platform technologies, the DNA-2-Go(TM) gene synthesis process and DeNovo Genes(TM), a protein engineering and sequence optimization technology. The company is also selling a large catalog of optimized synthetic genes at
their PlanetGene website (http://www.DNA20.com). For more information please visit http://www.DNA20.com or email
corpcom@DNA20.com.