GPS Technology

GPS Technology for Biological Engineering

GeneGPS

Combining Design of Experiment, Accurate Empirical Measurement and Machine Learning

At its core, Atum's GPS technology enables us to test small numbers of variants for commercially relevant properties, and to rapidly create molecules that work well in the real world. We call the platform "GPS" because it works similarly to a satellite system − it helps you to navigate the best path from your current position to your destination. The GPS platform is extremely versatile and can be applied to biological engineering at many levels including vector and gene optimization for expression in particular hosts, protein engineering for development of biocatalysts, and antibody humanization and affinity maturation.

REAL WORLD PERFORMANCE

REAL WORLD PERFORMANCE

High-quality low-throughput assays more precisely mimic the conditions that your protein will experience during its lifecycle. The result is a product that performs better in the real world, from manufacturing to its end-application.

SPEED TO MARKET

SPEED TO MARKET

ATUM's efficient workflow integrates in-house-media, assay, analytical and process development expertise. This accelerates project timelines and positions your protein for fast scale-up and manufacturing.

INTELLECTUAL PROPERTY

INTELLECTUAL PROPERTY

We can help you understand the IP landscape surrounding your protein. This translates to a stronger intellectual property position, giving you freedom to operate and broader patent claims, thereby reducing the risk of product obsolescence and being quickly overtaken by your competitors.

Applying the GPS Platform

GeneGPS®

VectorGPS®

Literature

In Silico Design of Functional DNA Constructs

ATUM's Gene Designer software enables design of novel vector combinations from genetic elements.

ProteinGPS®

Literature

Mapping of amino acid substitutions conferring herbicide resistance in wheat glutathione transferase

Application of ProteinGPS DOE and machine learning to characterize and understand substrate specificity of glutathione transferase in wheat.

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin

Collaboration with Pfizer using ProteinGPS to develop an aminotransferase with a 60-fold increase in activity in Vibrio fluvialis.

"Site and Mutation" − Specific Predictions Enable Minimal Directed Evolution Libraries

Collaboration with Merck illustrating application of ProteinGPS to improve activity of a transaminase in E. Coli.

AntibodyGPS®

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